Liquid-chromatographic measurement of taurine in cerebrospinal fluid of normal individuals and patients with meningitis.
Open Access
- 1 August 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 25 (8) , 1368-1369
- https://doi.org/10.1093/clinchem/25.8.1368
Abstract
Taurine was measured in cerebrospinal fluid by reacting it with fluorescamine to form a fluorescent derivative, followed by separation on a reversed-phase column and fluorometric detection and evaluation. The assay is rapid (17 min) and sensitive to as little as 1 mumol/L. The mean value for 27 cerebrospinal fluid samples collected from patients free from meningitis and aneurysm was 5.7 +/- 1.8 mumol/L. Twenty-two patients with bacterial meningitis showed a 0- to 20-fold increase in cerebrospinal fluid taurine, with a return to normal values after antibiotic treatment.This publication has 1 reference indexed in Scilit:
- STUDIES OF UNBOUND AMINO ACID DISTRIBUTIONS IN PLASMA, ERYTHROCYTES, LEUKOCYTES AND URINE OF NORMAL HUMAN SUBJECTSJournal of Clinical Investigation, 1960