Enantiospecific Synthesis of Analogues of the Diketide Intermediate of the Erythromycin Polyketide Synthase (PKS)
- 1 January 1998
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of Chemical Research
- No. 6,p. 283
- https://doi.org/10.1039/a800584b
Abstract
The four stereoisomers of 3-hydroxy-2-methylpentanoic acid (1a–d) and the structurally modified acids 1e–j have been synthesised enantiospecifically and converted into p-nitrophenyl ester and thioester derivatives; as the activated derivatives; they are available for investigations into the substrate selectivity of polyketide synthase (PKS) domains.Keywords
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