REDUCTION IN BRAIN SEROTONIN SYNTHESIS RATE IN STREPTOZOTOCIN-DIABETIC RATS1
- 1 July 1981
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 109 (1) , 310-312
- https://doi.org/10.1210/endo-109-1-310
Abstract
The rate of serotonin synthesis in brain was determined in streptozotocin-diabetic and normal rats using two methods. Both the rate of 5-hydroxytryptophan accumulation after aromatic amino acid decarboxylase inhibition, and the decline rate of 5-hydroxyindole acetic acid after pargyline treatment were significantly reduced in diabetic rats. The reduced rate of synthesis may be a direct result of significantly lowered brain tryptophan levels in diabetic rats.Keywords
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