Studies of clobazam and car‐driving.
Open Access
- 1 February 1979
- journal article
- clinical trial
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 7 (S1) , 85S-90S
- https://doi.org/10.1111/j.1365-2125.1979.tb04671.x
Abstract
1 The methodology used in studies to assess the effects of drugs on car‐ driving performance is reviewed. 2 Clobazam 20 mg, diazepam 10 mg or placebo were administered daily for 3 d to 24‐male students with a high neuroticism score (on the Cattell Personality Factors Questionnaire). 3 Car driving performance was assessed on the second day in real traffic conditions; tests of attention and concentration and subjective assessments were made on the third day. 4 Diazepam 10 mg significantly impaired braking reaction time in comparison with clobazam 20 mg and placebo (P less than 0.01). Subjects also reported feeling more 'depressed' and lethargic after diazepam.Keywords
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