A Method for the Study of the Effect of Barrier Creams and Protective Gloves on the Percutaneous Absorption of Solvents

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Abstract
Solvents were administered into closed skin depots on guinea pigs and the resulting blood concentrations were measured in samples repeatedly obtained via a catheter in the carotid artery. The exposure areas were protected with glove membranes or with barrier creams rubbed into the skin before administration of the solvents. Results from experiments with two solvents, various gloves and barrier creams with claimed protective effects are presented. It is concluded that this animal model seems suitable for screening purposes and capable of differentiating between various commercial products.