Liposome Entrapped Desferrioxamine and Iron Transporting Ionophores: a New Approach to Iron Chelation Therapy

1 March 1979

journal article
research article
Published by Wiley in British Journal of Haematology

Vol. 41 (3) , 357-363
https://doi.org/10.1111/j.1365-2141.1979.tb05868.x

Abstract

Summary. Liposome‐entrapped desferrioxamine was administered to iron‐overloaded ⁵⁹Fe labelled mice. When given orally or intraperitoneally entrapment did not enhance the effect of the chelator, but given intravenously liposomal desferrioxamine doubled the ⁵⁹Fe excretion for a given dose of the drug, and excretion after a single dose continued for up to 3 d. In addition, liposomes containing ionophore A23187 administered concurrently with DTPA caused an excretion of ⁵⁹Fe, whereas DTPA alone had no effect.

Keywords

IRON

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