Autocrine Growth of Murine Lymphoma Cells
- 16 March 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 80 (2) , 116-121
- https://doi.org/10.1093/jnci/80.2.116
Abstract
By using an assay system in which small numbers of murine T lymphoma cells are stimulated to grow in serum-free medium, we have continued and expanded our previous studies of an autocrine growth factor that we call leukemia-derived growth factor (LDGF). We show that a T lymphoma cell line of immature phenotype, adapted to growth in serum-free medium, produces and responds to LDGF. LDGF activity is distinct from activities of 10 highly purified or recombinant hematopoietic growth factors including IL-1 and IL-2. However, growth-stimulating activity for the murine lymphoma cells is provided by a partially purified human LDGF.Keywords
This publication has 7 references indexed in Scilit:
- Production of interleukin 1 by adult T cell leukemia (ATL) cell lines.The Journal of Immunology, 1987
- Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggeringCell, 1987
- Leukemia-derived growth factor (non-interleukin-2) produced by murine lymphoma T-cell lines.Proceedings of the National Academy of Sciences, 1984
- A NEW MURINE MODEL SYSTEM FOR THE IN VITRO DEVELOPMENT OF THYMOMA CELL HETEROGENEITY1984
- Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE).The Journal of Immunology, 1983
- T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for ActivityThe Journal of Immunology, 1978
- Adult T-cell leukemia: clinical and hematologic features of 16 casesBlood, 1977