Chromosomal Aberrations in Spontaneous Human Abortions

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Abstract
THIS study was stimulated by the classic discoveries of the association of chromosomal aberrations with several syndromes of multiple congenital anomalies1 2 3 4 5 followed by a rapid expansion of research activities in the field of human cytogenetics.6 It seemed reasonable to believe that since the syndromes already described were characterized by multiple anatomic anomalies and often by a "failure to thrive,"5 there were many more cases with similar or even more advanced chromosomal aberrations waiting to be discovered among the embryos and fetuses too severely handicapped to survive beyond the first trimester in utero. Such high hopes were only partially realized since . . .