Waterfall Sequence for Intrinsic Blood Clotting
- 18 September 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 145 (3638) , 1310-1312
- https://doi.org/10.1126/science.145.3638.1310
Abstract
A simple waterfall sequence is proposed to explain the function of the various protein clotting factors during the formation of the fibrin clot. When clotting is initiated, each cloting factor except fibrinogen is converted to a form that has enzymatic activity. This activation occurs in a sepwise sequence with each newly formed enzyme reacting with its specific substrate, converting it to an active enzyme.Keywords
This publication has 31 references indexed in Scilit:
- The mode of action of the Laki-Lorand factor in the clotting of fibrinogenBiochemical and Biophysical Research Communications, 1964
- A transamidase mechanism for insoluble fibrin formationBiochemical and Biophysical Research Communications, 1964
- The Assay of Heparin in Thrombin SystemsScandinavian Journal of Clinical and Laboratory Investigation, 1961
- The amino acid sequence of peptide B of co-fibrinBiochimica et Biophysica Acta, 1960
- The Role of Hageman Factor in the Initiation of Blood CoagulationBritish Journal of Haematology, 1959
- On the Amino Acid Sequence of Bovine Fibrinopeptides.Acta Chemica Scandinavica, 1959
- Variations in the Serum Total Cholesterol and Hematocrit Values in Normal Women During the Menstrual CycleScandinavian Journal of Clinical and Laboratory Investigation, 1959
- THE ACTIVE SITE OF THROMBINJournal of the American Chemical Society, 1958
- Intermediate Stages in the Formation of Blood ThromboplastinBritish Journal of Haematology, 1956
- The products of the action of thrombin on fibrinogenBiochimica et Biophysica Acta, 1952