A simplified route to a key intermediate in the synthesis of the Chinese nootropic agent huperzine A
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 1,p. 195-197
- https://doi.org/10.1039/p19900000195
Abstract
An efficient one-pot, three-component process for the preparation of 2-pyridones from a carbonyl compound, ammonia, and methyl propiolate has been found which provides ready access to a key intermediate in the synthesis of huperzine A.This publication has 1 reference indexed in Scilit:
- Preparation of substituted 2-pyridones by thermal rearrangement of propargylic pyrrolidine pseudoureasJournal of the American Chemical Society, 1980