Purification and characterization of mouse .ALPHA.1-acid glycoprotein and its possible role in the antitumor activity of some lichen polysaccharides.

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Abstract
Administration of some antitumor lichen polysaccharides (ALP) increased the serum level of .alpha.1-acid glycoproteins (.alpha.1-AG) in mice, possibly as a result of liver cell necrosis or inflammation induced by those polysaccharides. Ascites tumor-bearing mice were treated with ALP, and ascitic fluid having a high .alpha.1-AG level was harvested. Mouse .alpha.1-AG was obtained from this source in quantity, and fractionated into .alpha.1-AG-1 and -2. The time courses of the serum level of .alpha.1-AG and of the growth of subcutaneously implanted tumor were found to correlate well in ALP-treated mice, and purified .alpha.1-AG-1 inhibited the growth of tumor cells in vitro at a concentration normally observed in animals with inflammation. These results suggest that .alpha.1-AG plays a significant role in the antitumor activity exhibited by ALP.

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