Selective reactions between phenols and formaldehyde. A novel route to salicylaldehydes
- 1 January 1980
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 1862-1865
- https://doi.org/10.1039/p19800001862
Abstract
Treatment of phenols (1) with 2 mol equiv. of paraformaldehyde in aprotic and poorly electron-donating solvents in the presence of selected metal halides coupled with suitable bases produces salicylaldehydes (3) in high yields. The route is highly selective for ortho-formylation and also specific towards monoformylation. The crucial role of added bases is emphasized.Keywords
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