GENTAMICIN IN THE TREATMENT OF LOWER GENITAL-TRACT INFECTIONS - LEVEL OF THE DRUG IN MENSES, CERVICAL-MUCUS AND VAGINAL FLUID

  • 1 January 1979
    • journal article
    • research article
    • Vol. 17  (5) , 225-227
Abstract
The concentration of gentamicin in serum, menses, cervical mucus and vaginal fluid of 39 women under treatment with this antibiotic (80 mg every 8 h i.m.) was tested by the agar diffusion method. The levels of the drug in the serum varied from 1.88-5.41 .mu.g/ml with a peak 1 h after the last dosage. In the menses the levels ranged from 2.06-5.87 .mu.g/ml with a peak also 1 h after the last dosage. The concentration of gentamicin in the cervical mucus and vaginal fluid varied from 0.67-5.14 .mu.g/ml and 0.63-6.43 .mu.g/ml with a peak 3 h after the last administration of the drug. Results are briefly discussed.

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