Update of MACH-NC (Meta-Analysis of Chemotherapy in Head & Neck Cancer) database focused on concomitant chemoradiotherapy
- 15 July 2004
- journal article
- review article
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 22 (14_suppl) , 5505
- https://doi.org/10.1200/jco.2004.22.14_suppl.5505
Abstract
5505 Background: The MACH-NC Group have previously shown (Lancet; 2000) that chemotherapy (CT) improved survival (4% at 5 years) in non metastatic head and neck squamous cell carcinoma (HNSCC) treated by loco-regional treatment (LRT), with an higher benefit (8%) with CT concomitant to radiotherapy (RT). However the relatively important heterogeneity of the results limited the conclusions and prompted the MACH-NC to further confirm the results, by adding to the data base the data from the randomized trials performed between 1994 and 2000. Methods: Updated individual data from HNSCC patients randomized to LRT versus LRT + CT between 1965 and 2000 were included in this meta-analysis. The logrank-test, stratified by trial, was used for comparison and the hazard ratio (HR) of death was calculated. Results: 24 new trials, most of them on concomitant CT, were included totalizing 87 trials and more than 16,000 patients. The overall pooled HR was 0.88 (p<.0001) with an absolute benefit for CT of 5% at 5-years, and...Keywords
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