Complement Fixation in Conventional and Regressing Virus-Induced Murine Leukemia
Open Access
- 1 June 1971
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 106 (6) , 1488-1492
- https://doi.org/10.4049/jimmunol.106.6.1488
Abstract
Immunization of Swiss mice with conventional strains of murine leukemia virus did not elicit an appreciable humoral complement fixation (CF) response. In contrast, CF antibody was observed in mice infected with a virus that induced a spontaneously regressing leukemia. After infection with regressing Friend virus, (RFV), CF antibody was present in mice in which leukemia had regressed but was absent in leukemic mice. CF antibody elicited by RFV cross-reacted with other strains of murine leukemia virus.Keywords
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