HUMAN T-CELL ANTIGENS DEFINED BY MONOCLONAL-ANTIBODIES - ABSENCE OF T65 ON COMMITTED MYELOID AND ERYTHROID PROGENITORS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 56  (5) , 943-946
Abstract
The complement-dependent cytotoxicity of monoclonal T-cell antibody (T101) for normal and abnormal [human] hemopoietic progenitors was assessed. T101 demonstrated toxicity for normal T-colony-forming cells from peripheral blood and bone marrow. Cytotoxicity was absent for normal peripheral blood and bone marrow granulocyte/macrophage (CFU-C) and erythroid (BFU-E) progenitors. The antibody was also not toxic for peripheral blood blast progenitors from patients with acute myelogenous leukemia (AML). The antigen defined by T101 (T65) is apparently absent from normal progenitor cells and from blast progenitors in patients with AML. T101 may be used in the treatment of T-cell malignancies and in the prevention of graft-vs.-host disease (GVHD) without damage to normal progenitor cells.

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