Hyperglycemia Reduces Survival and Impairs Function of Circulating Blood-Derived Progenitor Cells
- 1 April 2005
- journal article
- research article
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 25 (4) , 698-703
- https://doi.org/10.1161/01.atv.0000156401.04325.8f
Abstract
Objective— Function and availability of circulating progenitor cells (CPC) have been shown to be impaired in patients with diabetes mellitus (DM). Therefore, the aim of the present study was to ana... In circulating progenitor cells (CPC), hyperglycemia induces cell-cycle arrest, impaired NO synthesis, and decreased migrational and integrative capacity. These mechanisms might contribute to the d...Keywords
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