First catalytic asymmetric synthesis of β-amino-β-polyfluoroalkyl ketones via proline-catalysed direct asymmetric carbon–carbon bond formation reaction of polyfluoroalkylated aldimines
- 29 July 2004
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 17,p. 1928-1929
- https://doi.org/10.1039/b406000h
Abstract
Proline-catalysed direct asymmetric carbon–carbon bond formation reaction of polyfluoroalkylated aldimines with acetone afforded the corresponding β-(p-methoxyphenyl)amino-β-polyfluoroalkyl ketones in high enantioselectivities (up to 98% ee).Keywords
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