First catalytic asymmetric synthesis of β-amino-β-polyfluoroalkyl ketones via proline-catalysed direct asymmetric carbon–carbon bond formation reaction of polyfluoroalkylated aldimines

Abstract
Proline-catalysed direct asymmetric carbon–carbon bond formation reaction of polyfluoroalkylated aldimines with acetone afforded the corresponding β-(p-methoxyphenyl)amino-β-polyfluoroalkyl ketones in high enantioselectivities (up to 98% ee).