Lithio-ketene-S,N-acetals: New Synthesis of Multifunctionalized 2-Pyridones
- 1 January 1986
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1986 (12) , 1063-1065
- https://doi.org/10.1055/s-1986-31878
Abstract
Lithioketene-S,N-acetal derived from N,N-dimethylthioacetamide reacts with aryl isocyanates to give monothiodiamides, which ware transformed into enaminonitriles by sulfide extrusion of the thioiminium salts with malononitrile. Bislithioketene-O,N-acetals, generated from the enaminonitriles with 2 equivalents n-butyllithium, react with a variety of electrophiles to afford multifunctionalized 2-pyridones.Keywords
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