Identification of benzoylcarnitine in the urine of a patient of hyperammonemia.
- 1 January 1989
- journal article
- research article
- Published by Tohoku University Medical Press in The Tohoku Journal of Experimental Medicine
- Vol. 159 (2) , 147-151
- https://doi.org/10.1620/tjem.159.147
Abstract
Benzoylcarnitine was identified in the urine of a patient with a carbamoyl-phosphate synthase I deficiency for whom sodium benzoate and L-carnitine had been used to treat hyperammonemia. This is a newly identified metabolize of benzoate. Its excretion in the urine was increased day by day at the administration of both sodium benzoate and L-carnitine from 0.10 to 2.25 mmol/g creatinine. Since there is the possibility of a secondary carnitine deficiency and an increase of benzoyl toxicity after long-term therapy with benzoate supplementation and protein restriction, it is important to monitor the urinary excretion of benzoylcarnitine.This publication has 2 references indexed in Scilit:
- The potentiation of ammonia toxicity by sodium benzoate is prevented by L-carnitineBiochemical and Biophysical Research Communications, 1987
- Identification of glutarylcarnitine in glutaric aciduria type 1 by carboxylic acid analyzer with an ODS reverse-phase columnClinica Chimica Acta; International Journal of Clinical Chemistry, 1987