Symptomatic benefit 1-3 years after h. pylori eradication in ulcer patients: impact of gastroesophageal reflux disease

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Abstract
Eradication of Helicobacter pylori (H. pylori) infection markedly reduces the recurrence of duodenal and gastric ulcers. However, there is little information regarding its efficacy in resolving dyspeptic symptoms in ulcer patients. The primary aim of this study was to assess the effect of eradicating H. pylori infection on dyspeptic symptoms in ulcer patients. The secondary aim was to identify predictors of symptomatic response to H. pylori eradication. A total of 97 dyspeptic patients with active duodenal and/or gastric ulceration associated with H. pylori infection and unrelated to NSAID use had the severity and character of their dyspeptic symptoms measured before and again 1–3 yr after H. pylori eradication therapy. Pretreatment, the median dyspepsia score was 12 (4, 5, 6, 7, 7, 8, 9, 10, 11, 12, 13, 14, 15, <a id="ref-link-abstract-14" title="Jaspersen, D, Koerner, T, Schorr, W, et al. Helicobacter pylori eradication reduces the rate of rebleeding in ulcer hemorrhage. Gastrointest Endosc 1995;41:5–7." href="/articles/ajg200023#ref16" aria-label="Reference 16" data-track="click" data-track-action="reference anchor"...