Role of pyridoxine in glutathione metabolism

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Abstract
The effect of pyridoxine deficiency induced under various dietary regimens, on the concentration of non-protein SH compounds (essentially GSH) glutathione in erythrocytes and tissues was studied in rats. Deficiency of pyridoxine resulted in an elevation of GSH concentrations in erythrocytes and liver, but not in kidneys, spleen and brain. An increase of GSH concentration in liver was also observed when pyridoxine-deficient rats received a diet free of cysteine or glutamic acid. The incorporation of [2-C14]glycine and [1-C14]glutamic acid into the GSH moiety was enhanced by pyridoxine deficiency. It is suggested that pyridoxine is an important regulator in glutathione metabolism.