Drugs with Antithrombotic Effect: Experimental Study

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Abstract
The in vitro and the in vivo [in rats] antithrombotic effect of some drugs [acetylsalicyclic acid (ASA), heparin, dipyridamole (DIPY), lysine-acetylsalicylate (LASA) and prometazin] and drug associations were compared with their antihypoxic effect. The same doses of drugs as that for clinical purposes were used. The experimental model described by Duval, which consists of the electric stimulation by a fine Pt wire of mesenteric arteries of uretane-anesthetized rats with a continuous cathodal current of 300 mA during 30 s, was employed. The results obtained experimentally could be a justification of the clinical use of antithrombotic drug associations: either heparin-DIPY (and prometazin) or ASA-DIPY (and prometazin). The increase of brain resistance to hypoxia by heparin and prometazin could be an interesting action in the treatment of DIC[disseminated intravascular coagulation].

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