Effect of deoxycholic acid on colonic motility in the rabbit

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Abstract
The effect of the bile salt deoxycholic acid [DCA] on colonic myoelectrical and contractile activity recorded from a loop of proximal colon in the anesthetized rabbit was determined. Myoelectrical activity was recorded from bipolar electrodes attached to the serosal surface of the proximal colon. Contractile activity of the circular smooth muscle was measured with a strain gauge attached in the circular direction on the serosal surface of the colonic loop. The colonic slow wave frequency was 12.5 .+-. 1.1 cycles/min. The slow wave frequency throughout the loop was homogeneous with a low coefficient of variation of the slow wave frequency (5.8 .+-. 0.3). There were spike potentials superimposed on 78.1 .+-. 3.4% of the slow waves. The additon of 8 or 16 mM DCA did not change the slow wave or spike activity. DCA stimulated a dose-dependent increase in migrating action potential complexes. These complexes were associated with a forceful contraction of the circular smooth muscle that propelled luminal contents in the direction of the burst. DCA also stimulated an increase in luminal fluid content.

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