PLASMA RENIN ACTIVITY, BLOOD PRESSURE AND SODIUM EXCRETION DURING TREATMENT WITH CLONIDINE
- 12 January 1975
- journal article
- Published by Wiley in Acta Medica Scandinavica
- Vol. 197 (1-6) , 457-461
- https://doi.org/10.1111/j.0954-6820.1975.tb04951.x
Abstract
Clonidine, 225 mug a day, has been given orally for 3 months to 15 patients with essential hypertension. Mean BP was reduced from 159/107 to 143/87 mmHg. The antihypertensive effect of the drug was dissociated from changes in plasma renin activity (PRA) during clonidine treatment. PRA levels decreased initially in 6 patients with the highest PRA values before treatment, but then increased again. In 6 patients with lower pretreatment PRA levels, PRA rose continuously. Opposite patterns of 24-hour urinary sodium excretion were observed in these arbitrary subgroups. The antihypertensive effect of clonidine in essential hypertension appears to be independent of changes in PRA.Keywords
This publication has 6 references indexed in Scilit:
- Essential Hypertension: Renin and Aldosterone, Heart Attack and StrokeNew England Journal of Medicine, 1972
- Acute effects of clonidine on central and peripheral haemodynamics and plasma renin activityEuropean Journal of Clinical Pharmacology, 1972
- Antihypertensive Effect of ClonidineCirculation Research, 1971
- Determination of Plasma Renin Concentration by Angiotensin I ImmunoassayCirculation Research, 1971
- Suppression of Renin and Aldosterone by Clonidine.Annals of Internal Medicine, 1971
- Studies on catecholamines, renin and aldosterone following catapresan® (2-(2,6-dichlor-phenylamine)-2-imidazoline hydrochloride) in hypertensive patientsEuropean Journal of Pharmacology, 1970