ANIMAL-MODELS FOR AN INTEGRATED APPROACH TO THE PHARMACOLOGIC CONTROL OF ATHEROSCLEROSIS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 5  (2) , 90-109
Abstract
A system of animal models useful for the discovery and evaluation of new effective antiatherosclerotic agents is described. The models consist of a series of lipoprotein and atherosclerosis assays in rats, SEA Japanese quail and cynomolgus monkeys (Macaca fascicularis). SEA quail are useful for detecting compounds that inhibit arterial cholesterol deposition. The use of the integrated system of models is illustrated with data on clofibrate, adamantyloxyaniline (a hypobetalipoproteinemic agent) and o,p''-DDD. Male SEA quail are a satisfactory model for testing the effects of large numbers of compounds on atherosclerosis.