Structures of new antibiotics napyradiomycins.
- 1 January 1986
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 39 (4) , 494-501
- https://doi.org/10.7164/antibiotics.39.494
Abstract
Structures of novel antibiotics, napyradiomycins A, B1, B2, B3 C1 and C2 were determined. By X-ray crystallography, napyradiomycin B2 was determined to be (3R,10aR)-3-chloro-10a-[[(1R,3S)-3-chloro-2,2-dimethyl-6-methylenecyclohexyl]methyl]-3,10a-dihydro-6,8-dihydroxy-2,2-dimethyl-2H-naphtho[2,3-b]pyran-5,10-dione. The structures of other napyradiomycins were elucidated by NMR studies. Napyradiomycins C1 and C2 have unique structures and contain 14-membered ring cyclized by carbon-carbon bond.This publication has 2 references indexed in Scilit:
- Novel antibiotics napyradiomycins. Production, isolation, physico-chemical properties and biological activity.The Journal of Antibiotics, 1986
- Recent Developments in 13C-and Proton-NMRJournal of Natural Products, 1984