The gene for incontinentia pigmenti: failure of linkage studies using DNA probes to confirm cytogenetic localization

1 July 1988

journal article
research article
Published by Wiley in Clinical Genetics

Vol. 34 (1) , 1-6
https://doi.org/10.1111/j.1399-0004.1988.tb02607.x

Abstract

Probes for restriction fragment length polymorphisms mapping between Xp21 and Xq22.3 have been used in a linkage study of incontinentia pigmenti (IP). Six independent sporadic cases of disorders resembling IP with X-autosome translocations involving the same X chromosome breakpoint (Xp 11) have been reported. These observations suggest that IP gene may be located in the Xp11 chromosomal region. However, the linkage study with DNA probes has failed to confirm this localisation.

Keywords

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