Burkitt's and Other Non-Hodgkin's Lymphomas in Adults Exposed to a Visitor from Africa

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Abstract
DISEASE clustering, the occurrence of cases that are close together in time and space, is often believed to suggest an infectious cause.1 , 2 Despite numerous anecdotal reports of cancer clusters, Burkitt's lymphoma is the only human cancer for which there is clear-cut statistical evidence of time—space clustering.2 3 4 In general, reports of cancer clusters are uninformative, since most cancers have long, variable, or unknown latency periods between etiologic exposure and manifestation of the disease.2 , 4 , 5 A typical reported cluster is characterized by proximity in the time of diagnosis and in the residence of patients at diagnosis. However, the etiologic exposure may have occurred . . .

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