Abstract
Two pairs of cardio-accelerators and one pair of cardio-inhibitors run from the thoracic ganglion to the cardiac ganglion in Panulirus argus, the Bermuda spiny lobster. When electrically stimulated, these cause effects on the heart which are related to the frequency and strength of stimulation. Inhibition and acceleration show facilitation and an after-effect, but differ in the time course of their respective action. These extrinsic cardio-regulator nerves probably exert their effect by direct action upon the excitabilities of the cardiac ganglion cells.

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