Serum lipoprotein profile in children from a biracial community: the Bogalusa Heart Study.

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Abstract
Serum lipoprotein profiles in 3182 children, ages 5-14 yr, were studied in a biracial community as part of the Bogalusa [Louisiana, USA] Heart Study to describe the early natural history of atherosclerosis. White and black children showed similar mean levels of .beta.-lipoproteins. Pre-.beta.-lipoprotein levels were significantly higher in white children, while significantly higher levels of .alpha.-lipoprotein were found in black children. Girls had generally higher levels of .beta.- and pre-.beta.-lipoprotein and lower levels of .alpha.-lipoprotein than boys, although the differences were not significant at each age group. With age there was little change in .alpha.-lipoprotein levels, a significant increase in pre-.beta.-lipoprotein levels and a slight but significant decrease between 11-14 yr in .beta.-lipoprotein levels. The correlation of .alpha.-lipoprotein was negative with .beta.-lipoprotein and, to a greater extent, with pre-.beta.-lipoprotein. The above inverse relationships were significantly greater in white children than in black children, suggesting differences in lipoprotein profiles in the 2 groups. Lipoprotein values from a total community study are now available for comparison with the currently recommended upper normal limits for lipoproteins. Since only a very small percentage of children could be considered as hyperlipoproteinemic by those specific levels in this community, distributions and percentiles should be used to evaluate children for hyperlipoproteinemia.

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