Original article: Evaluation of oil-soluble FUdR ester for transcatheter arterial treatment of hepatomas
- 1 May 1992
- journal article
- clinical trial
- Published by Elsevier in Annals of Oncology
- Vol. 3 (5) , 367-370
- https://doi.org/10.1093/oxfordjournals.annonc.a058208
Abstract
From January 1987 to December 1989, we performed a prospective study of transcatheter arterial chemo-embolization therapy with iodized oil (Lipiodol) mixed with an anticancer agent. A new oil-soluble modification of FUdR, FUdR-C8 ester, was developed and dissolved in Lipiodol as an embolic material, which was administered to 36 patients with hepatomas. Water-soluble adriamycin emulsified in Lipiodol was used as control in 67 patients with hepatomas. Initial effects on tumors were observed as decrease of tumor size in 25.0% for the FUdR group and17.9% for the control group. Alpha-fetoprotein decreased more than half in 41.9% of the FUdR group, and 16.1% of the ADM group. Six-month and one-year survivals were 74.2% and 46.8% for the FUdR group (median survival 317 days), whereas the control group yielded 61.0% and 28.3% survivals, respectively (median survival 191 days).Keywords
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