Quantitative measurement of time‐dependent thallium distribution in organs of mice by field desorption mass spectrometry

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Abstract
The time-dependent distribution of the toxic heavy metal Tl in mouse organs was determined after feeding 80, 130 and 160 mg/kg Tl. Quantitative measurements were performed by field desorption mass spectrometry with stable isotope dilution. No pretreatment of the tissue samples, other than homogenizing and centrifugation, was necessary. The precision of the data was about .+-. 10%. Heart, liver, kidney and stomach showed an organ-specific initial uptake of Tl during the first 2-3 h. This was followed by a period of washout to relatively low Tl levels. Brain Tl uptake was comparatively low and constant during the first 12 h. In the terminal stage (24 h) all organs, including the brain, contained increased Tl levels of the same order of magnitude.