Presynaptic inhibition by baclofen of miniature EPSCs and IPSCs in substantia gelatinosa neurons of the adult rat spinal dorsal horn
- 1 April 2000
- journal article
- Published by Wolters Kluwer Health in Pain
- Vol. 85 (3) , 385-393
- https://doi.org/10.1016/s0304-3959(99)00285-7
Abstract
Intrathecal administration of baclofen, a GABAB-receptor agonist, affects pain behavior induced by formalin in a biphasic manner; baclofen at low doses enhances pain while producing antinociception at high doses. This may be due to the fact that baclofen modulates each of excitatory and inhiKeywords
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