Ceftriaxone
- 1 January 1985
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 103 (1) , 71-72
- https://doi.org/10.1001/archopht.1985.01050010075024
Abstract
• One- or two-gram doses of ceftriaxone were administered intravenously to 30 patients before cataract extraction. With the 1-g dose, mean aqueous humor concentrations of 0.93 and 0.88 μg/mL were found at approximately 2 and 12 hours after administration, respectively. With the 2-g dose, a mean level of 2.47 μg/mL was observed at two hours; levels of more than 2 μg/mL were found in two patients 13 hours after administration. Both the 1- and 2-g doses thus produce aqueous humor levels many times higher than the minimum inhibitory concentration of ceftriaxone for 90% of most Enterobacteriaceae, excluding Pseudomonas. Concentrations adequate for Staphylococcus aureus and Staphylococcus epidermidis were not, however, obtained.This publication has 2 references indexed in Scilit:
- Comparative in vitro studies of Ro 13-9904, a new cephalosporin derivativeAntimicrobial Agents and Chemotherapy, 1981
- Etiology and Diagnosis of Bacterial Postoperative EndophthalmitisOphthalmology, 1978