Radioimmunoassay for Clonidine in Human Plasma and Urine Using a Solid Phase Second Antibody Separation
- 1 September 1985
- journal article
- research article
- Published by Wolters Kluwer Health in Therapeutic Drug Monitoring
- Vol. 7 (3) , 344-350
- https://doi.org/10.1097/00007691-198507030-00020
Abstract
A reliable, sensitive, and specific radioimmunoassay (RIA) procedure for the quantitation of clonidine in plasma and other biological fluids was developed. The detection limit of the assay is 2 pg based on a 200 .mu.l sample. Nine commonly used drugs were found not to interfere with the RIA. The utility of the assay was demonstrated in a bioavailability study of clonidine conducted with 24 healthy subjects. Clonidine was readily quantitated in plasma over 4 half-lives. This assay is suitable for pharmacokinetic and bioavailability studies as well as therapeutic drug monitoring of patients.This publication has 1 reference indexed in Scilit:
- New aspects of the pharmacokinetics and pharmacodynamics of clonidine in manEuropean Journal of Clinical Pharmacology, 1983