Increased serum concentrations of interleukin-2 receptor in the first trimester in women who later developed severe preeclampsia
Open Access
- 11 June 1998
- journal article
- research article
- Published by Wiley in Acta Obstetricia et Gynecologica Scandinavica
- Vol. 77 (6) , 591-593
- https://doi.org/10.1034/j.1600-0412.1998.770602.x
Abstract
To determine the concentration of cytokines having an immunomodulating effect in the first trimester in women who subsequently developed preeclampsia. The serum concentrations of IL-10, TNFalpha, IL-6 and IL-2R were determined in ten women who later developed severe preeclampsia and in ten healthy controls. The groups were compared with the Mann-Whitney U test. The IL-2R concentration was significantly higher in the women who later developed preeclampsia than in normal patients (p = 0.028). No significant differences were detected between the groups with respect to the other evaluated cytokines. Elevated IL-2R concentrations in maternal serum as early as in the first trimester may be a sign of immunological maladaptation and might be associated with a disturbance of trophoblastic invasion.Keywords
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