The Effect of Metabolic and Respiratory Acidosis on Cardiac Functions
- 1 January 1970
- journal article
- Published by Japanese Circulation Society in Japanese Circulation Journal
- Vol. 34 (2) , 61-67
- https://doi.org/10.1253/jcj.34.61
Abstract
Experiment was undertaken to evaluate the effects of acidosis upon the susceptibility of the heart by measuring digitalis tolerance, myocardial contractility, and ventricular fibrillation thresh-old. The significant reductions in acetyl stro-phanthidin tolerance, left ventricular contractile force, and ventricular fibrillation threshold value were found during metabolic acidosis induced by lactic acid infusion, whereas they were maintained at almost control values during respiratory acidosis. Moreover, the decreased myocardial contractility after total body perfusion was relative to the decreased arterial blood pH caused by the metabolic factor.Keywords
This publication has 0 references indexed in Scilit: