Effect of absorption promoters in intranasal administration of human fibroblast interferon as a powder dosage form in rabbits.

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Abstract
The utility of the absorption promoters, sodium glycocholate (GC-Na), ethylenediamine dihydrochloride (EDTA-2Na), sodium caprylate (Cap-Na) and sodium salicylate (Sal-Na), in the intranasal administration of human fibroblast interferon-.beta. (HuIFN-.beta.) in rabbits was investigated. The optimal amount of added EDTA-2Na, Cap-Na and Sal-Na with respect to HuIFN-.beta. was examined for nasal absorption in the powder dosage form. Formations of HuIFN-.beta. with GC-Na showed greatly enhanced intranasal HuIFN-.beta. absorption, as compared to the other absorption promoters. The results of a stability study on HuIFN-.beta. in homogenates of nasal mucosa suggested that GC-Na behaved as a hydrolysis inhibitor in the nasal mucosa and maintianed the activity of HuIFN-.beta.