Effect of Ethanol on Liver Triglycerides and Fatty Acid Composition in the Golden Syrian Hamster

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Abstract
In choice situations, the golden Syrian hamster shows a strong preference to drink an ethanol solution to water alone. Because of the effects of ethanol on lipid metabolism, its effects on liver fatty acids were studied in the hamster. After a period of 8 wk during which hamsters had consumed water containing 10% ethanol (4 wk) and then 15% ethanol (4 wk), the liver was significantly increased in weight, an effect which was due to fat accumulation as triglyceride. The fatty acid composition of the liver triglycerides and phospholipids was altered such that monounsaturated fatty acids were very significantly increased and both n-6 and n-3 essentially fatty acids were proportionally decreased.