Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ‐1 (T497C) genes in familial Parkinson's disease from the GenePD study
- 17 June 2005
- journal article
- research article
- Published by Wiley in Movement Disorders
- Vol. 20 (9) , 1188-1191
- https://doi.org/10.1002/mds.20515
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder in which relatives of the probands are affected approximately 4 times as frequently as relatives of control subjects. Several genes have been implicated as genetic risk factors for PD. We investigated the presence of six reported genetic variations in the SCNA, NR4A2, and DJ‐1 genes in 292 cases of familial Parkinson's disease from the GenePD study. None of the variants were found in the GenePD families. Our results suggest that other variants or genes account for the familial risk of PD within the GenePD study. © 2005 Movement Disorder SocietyKeywords
This publication has 8 references indexed in Scilit:
- A limited role for DJ1 in Parkinson disease susceptibilityNeurology, 2004
- Extended mutation analysis and association studies of Nurr1 ( NR4A2 ) in Parkinson diseaseNeurology, 2004
- Mutations in NR4A2 associated with familial Parkinson diseaseNature Genetics, 2002
- Epidemiologic study of 203 sibling pairs with Parkinson’s diseaseNeurology, 2002
- Clinical features of parkinsonian patients with the α‐synuclein (G209A) mutationMovement Disorders, 2001
- High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometryProceedings of the National Academy of Sciences, 2001
- AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's diseaseNature Genetics, 1998
- Mutation in the α-Synuclein Gene Identified in Families with Parkinson's DiseaseScience, 1997