Guillain-Barré Syndrome After Influenza Vaccination in Adults

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Abstract
In 1976, the United States implemented the National Influenza Immunization Program in anticipation of a swine influenza epidemic that never materialized. This program was discontinued prematurely, in part because of reports of Guillain-Barré syndrome (GBS) among those vaccinated. Subsequent analyses suggested that individuals who received this vaccine were at a 4- to 8-fold risk for developing GBS.1 The threat of an influenza pandemic has again prompted policy makers to consider the possibility of instituting mass influenza vaccination programs as a preventive measure.2 However, uncertainty remains about the potential risk for GBS that may be associated with such initiatives.