INTRAVESICAL INSTILLATION OF ADRIAMYCIN - A MODEL FOR STANDARDIZATION OF THE CHEMOTHERAPY

  • 1 January 1980
    • journal article
    • research article
    • Vol. 6  (4) , 218-220
Abstract
Intravesical instillation of adriamycin was successfully used in the treatment of [human] bladder tumors. The adriamycin concentration in the bladder was monitored. The area under the bladder concentration-time curve (AUC) should be considered, rather than the amount of instilled drug, when optimizing the treatment schedules. pH effects which may arise in the bladder when instilling protolytic drugs like adriamycin are discussed.