Development and in Vitro Evaluation of Systems to Protect Peptide Drugs from Aminopeptidase N
- 1 January 1997
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 14 (2) , 181-185
- https://doi.org/10.1023/a:1012096510125
Abstract
Purpose. Develop and evaluate systems to prevent aminopeptidase N caused enzymatic degradation of perorally administrated peptide drugs. Methods. Bacitracin was covalently bound to the unabsorbable...Keywords
This publication has 7 references indexed in Scilit:
- A mixture of Manduca sexta aminopeptidase and phosphatase enhances Bacillus thuringiensis insecticidal CryIA(c) toxin binding and 86Rb(+)-K+ efflux in vitro.1994
- Enzymatic barriers for GI peptide and protein delivery.1994
- Dissociation of the antimicrobial activity of bacitracin USP from its renovascular effectsAntimicrobial Agents and Chemotherapy, 1992
- The Use of α-Aminoboronic Acid Derivatives to Stabilize Peptide Drugs During Their Intranasal AbsorptionPharmaceutical Research, 1989
- Identification of inhibitors of urinary alanine aminopeptidaseClinica Chimica Acta; International Journal of Clinical Chemistry, 1986
- Enhancement by N-hydroxysulfosuccinimide of water-soluble carbodiimide-mediated coupling reactionsAnalytical Biochemistry, 1986
- Purification and properties of human intestine alanine aminopeptidaseBiochimica et Biophysica Acta (BBA) - Enzymology, 1980