The Role of Oxalates on the Incidence and Extent of Dental Caries in the Cotton Rat (Sigmodon Hispidus Hispidus)

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Abstract
66 weanling cotton rats were placed on a sugar caries-producing synthetic diet, and K oxalate in varying concs. was added to the drinking water of selected groups. Litter mates served as controls on a comparable diet without oxalates. At the end of the 14 wk. exptl. period necessary to produce the desired degree of dental caries, all rats were sacrificed and their teeth examined for incidence and extent of carious lesions. Statistical analysis of the results ruled out any effect of oxalates on either the incidence or extent of carious lesions. Cellulose added tq the diet of one group of rats did not influence the caries picture but was found essential to prevent hair-ball formation and mortality incident thereto.

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