Cryofibrinogenemia, Monoclonal Gammopathy, and Purpura

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Abstract
A patient with purpura, acral blisters, and ulcerations was evaluated and found to have cryofibrinogenemia and an IgG K light chain monoclonal gammopathy. No other systemic illness was found. The overall incidence of significant cryofibrinogenemia in hospitalized patients is 3%. Four categories of secondary cryofibrinogenemia include neoplastic, thrombotic, infectious, and miscellaneous disorders. The patient described was not easily classified. This case is probably best considered primary or idiopathic cryofibrinogenemia. (Arch Dermatol 115:208-211, 1979)

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