Long-term Proton Pump Inhibitor Therapy and Risk of Hip Fracture
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Open Access
- 27 December 2006
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 296 (24) , 2947-2953
- https://doi.org/10.1001/jama.296.24.2947
Abstract
More than 47 000 hip fractures occur annually in the United Kingdom.1 Hip fracture is the main manifestation of senile osteoporosis, which results from secondary hyperparathyroidism associated with calcium malabsorption, low calcium intake, and other factors.2 Among the various forms of low-trauma fractures, hip fracture leads to the most devastating consequences. The mortality rate during the first year after a hip fracture is 20%.3,4 Among those who survived this period, 1 in 5 requires nursing home care.5 In addition, hip fractures invariably require an emergency department visit, hospitalization, surgery, and rehabilitation, incurring huge health care costs.Keywords
This publication has 1 reference indexed in Scilit:
- Hypochlorhydria from short-term omeprazole treatment does not inhibit intestinal absorption of calcium, phosphorus, magnesium or zinc from food in humans.Journal of the American College of Nutrition, 1995