Plasma Adrenocorticotropin, Cortisol, and Dehydroepiandrosterone Response to Corticotropin-Releasing Factor in Normal Children during Pubertal Development

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Abstract
The adrenocorticotropin (ACTH), Cortisol, and dehydroepiandrosterone responses to synthetic human corticotropin-releasing factor (CRF) were studied in 28 endocrinologically healthy children (age 1–16 yr) and in six adult volunteers (age 24–42 yr). CRF was given as an intravenous bolus (1 μg/kg body weight) between 0900 and 1000 hr. Significant increments in ACTH and Cortisol levels after CRF were observed in all subjects, with an ACTH peak value of 48.2 ± 3.4 pg/ml at 10 min (p < 0.001). The ACTH and Cortisol response patterns after CRF did not change with age or pubertal maturation and did not differ in children and in adults. In contrast, the dehydroepiandrosterone response to CRF clearly was related to the stage of pubertal development. The peak value after CRF significantly increased from puberty stage 1 to puberty stage 5 (164 ± 18 versus 779 ± 86 ng/100 ml, p < 0.001). In adults, the mean dehydroepiandrosterone peak value after CRF did not differ from that of P5 children. These results show that CRF can be given safely to children. The absence of age-dependent ACTH and Cortisol responses and a dehydroepiandrosterone response changing with pubertal maturation points to the existence of factors involved in the control of adrenal androgen production other than ACTH.

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