Alterations in Human-Platelet Serotonin Uptake Following the Addition of Thrombin or A 23187

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Abstract
The data presented suggests that treatment with thrombin or A23187, in addition to inducing vesicle release, markedly alters the plasma-membrane uptake of 5HT [5-hydroxytryptamine]. These results, which parallel to some extent those of others, delineate a significant advantage to the use of thrombin for studies of 5HT uptake; once a high dose of thrombin is added, only a very small amount of 5HT uptake occurs during the subsequent release period. A large proportion of the 5HT remaining in a platelet population following induction of maximal release then represents 5HT added prior to the onset of the release reaction.

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