Pigeon breeder's lung: association with HLA‐DR 3

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Abstract
52 symptomatic (SPB) and 64 asymptomatic (APB) pigeon breeders were investigated for the HLA‐A,‐B,‐C,‐DR; C2,C3,C4 and Bf systems, and C3, C4 and factor B serum concentrations. HLA‐DR3 and Bf S frequencies were significantly higher in the SPB than the APB group. Mean factor B concentrations were lower in the SPB than in the APB group. A positive two‐way association between HLA‐DR3 and the disease was found. It is concluded that a gene or genes responsible for type III and IV allergic reactions leading to the disease is associated with HLA‐DR3. The increase of Bf S allotype and low mean factor B concentrations, however, can be explained by the strong linkage disequilibrium between Bf5 and HLA‐DR3.